Magic truffles against depression: what does science say?
While not much specific research has yet been done on magic truffles themselves, extensive research has been conducted on the main active ingredient: psilocybin. This research offers hopeful insights, especially in the treatment of depression. However, one major drawback of these studies is that they often do not include the so-called "entourage effect". This entourage effect means that it is the combination of all substances in the truffle that enables the healing effect, not just the psilocybin.
Clinical studies: how effective is psilocybin in depression?
Several clinical studies have been conducted worldwide investigating psilocybin in combination with psychotherapeutic counselling. Below is a summary of the most notable studies:
Phase 2 dose comparison in treatment-resistant depression
A randomised, double-blind study showed that a single dose of 25 mg of psilocybin was significantly more effective than placebo. Patients experienced significant reductions in depressive symptoms within three weeks, with the positive effects persisting for longer periods of time.
Largest-ever phase 3 study (COMP360)
Compass Pathways is currently conducting the largest phase 3 study of psilocybin in treatment-resistant depression. Results from thousands of participants are expected soon, which will provide further clarity.
Johns Hopkins Study (12-month follow-up)
Johns Hopkins research found that 75% of the participants responded to treatment with psilocybin, while 58% achieved complete remission within a year.
Systematic review (JAMA Psychiatry)
A systematic review concluded that psilocybin can rapidly and persistently reduce depressive symptoms in major depressive disorder (MDD) under controlled conditions.
Comparison with conventional antidepressants
According to a recent network meta-analysis, high-dose psilocybin shows potentially stronger effects than the common antidepressant escitalopram, although the quality of the evidence requires further investigation.
Global research on chronic pain and cluster headaches
Besides depression, psilocybin also shows promising results in conditions related to pain:
Cluster headache (Yale University)
Yale University conducted a randomised trial in which psilocybin was found to be effective in reducing cluster headache attacks. Similar positive results were also found in Denmark.
Migraine and other pain studies
Ongoing studies are currently investigating psilocybin as a treatment for migraine and phantom pain, supported by preclinical results showing long-term pain relief.
How does psilocybin work in the brain?
Scientists point to several possible mechanisms of action:
- Serotonergic effect: Psilocybin activates certain serotonin receptors involved in mood and pain perception.
- Neuroplasticity: Neuroimaging studies show that psilocybin can cause long-term changes in brain activity, possibly contributing to long-term effects.
- Ego-dissolution and mystical experiences: Studies have shown that profound mystical experiences during a psilocybin session are strongly associated with positive psychological outcomes.
Safe use of Magic Truffles
Despite these positive results, it remains essential to always use Magic Truffles with care and professional guidance. At MicrodosingXP, we stress that safe and responsible use of psychedelics is crucial, especially in the context of mental health.
Want to know more?
Want to know more about Magic Truffles, their application and where to buy them safely? Then visit our points of sale page (https://microdosingxp.com/nl/verkooppunten/) for a list of reliable providers.
At MicrodosingXP, we believe in the power of nature: pure and unchanged, exactly as Mother Earth intended.